Abstract
Photodynamic therapy (PDT) is an effective and new method for tumor therapy but limited by the poor penetration depth of tissue of ultraviolet or visible light as irradiation source. Herein a near-infrared light-responsive W18O49 nanoprobe was synthesized by the solvothermal method for PDT. The structure, morphology, infrared absorption property and the photodynamic performance were analyzed. The results showed that the samples had high crystallinity, uniform and dispersed spindle morphology and an obvious absorption of NIR light. Under the irradiation of 808 nm near-infrared light, 1,3- diphenylisobenzofuran (DPBF) was used as a capture agent for singlet oxygen, and the samples showed excellent photodynamic performance. Then in vitro cell experiments further indicated that the samples good biocompatibility and an evident inhibition effect on tumor cell growth under near-infrared irradiation. The nanoprobe will have a wide application prospect in photodynamic cancer therapy.
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