Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology

Abstract

Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.