Study on the mechanism of interleukin in the pathogenesis of the patients with vascular dementia and impaired glucose tolerance

Abstract

Objective To investigate the effect of interleukin on the pathogenesis of the disorder with vascular dementia and impaired glucose tolerance. Methods One hundred cases of vascular dementia that met the designed standards were chosen as research subjects and were divided into 2 groups: i. e. the vascular dementia with normal glucose tolerance group and the vascular dementia with impaired glucose tolerance group, each consisting of 50 cases. Then, 50 healthy examinees were randomly chosen as the control group. Fasting blood sugar levels, blood sugar levels 2 hours after meal and IL-2, IL-6, IL-17and IL-18 levels of the 3 groups were detected. Mini-mental state exam (MMSE) was evaluated on all the patients with vascular dementia. Results Detection results of blood sugar levels 2 hours after meal indicated that the level of the vascular dementia with impaired glucose tolerance group was [(8.96±1.02) mmol/L], which was higher than that of the vascular dementia with normal glucose tolerance group [(6.65±0.83) mmol/L], which was even higher than that of the healthy control group [(6.59±0.78) mmol/L], and statistical significance could be seen, when comparisons were made between them(P<0.01). Detection results showed that the levels of IL-2, IL-6, IL-17and IL-18 of the vascular dementia with impaired glucose tolerance group was higher than that of the vascular dementia with normal glucose tolerance group, and that of the vascular dementia with impaired glucose tolerance group was obviously higher than that of the vascular dementia with normal glucose tolerance group(P<0.05). Statistical differences could be noted in MMSE scores and ADL scores, when comparisons were made between them(P<0.05). Detection results indicated that the MMSE and ADL scores of the vascular dementia with impaired glucose tolerance group was lower than that of the vascular dementia with normal glucose tolerance group(P<0.05), and that of the vascular dementia with impaired glucose tolerance group was higher than that of the vascular dementia with normal glucose tolerance group(P<0.05). Conclusions Results showed that interleukin was involved in the occurrence and development of vascular dementia. Cerebral blood vessels with impaired glucose tolerance were more likely to be affected by vascular dementia, and furthermore dementia symptoms were usually severer. Key words: Interleukin; Impaired glucose tolerance; Vascular dementia