Abstract
Lonicera japonica has been studied extensively by scholars at home and abroad, a number of compounds have been isolated from it, which mainly include organic acids and flavonoids. Pharmacological studies have shown that Lonicera japonica has antibacterial and gall bladder-protective effects. To study the active constituents in Lonicera japonica and the mechanism of their anti-upper respiratory tract infection action in children. Compounds were identified by chromatographic methods, and the mechanism of anti-pediatric upper respiratory tract infection action of Lonicera japonica decoction was studied using experimental animals. A total of four compounds were isolated, after injection of egg white, toe edema in rats in the control group was very obvious, different test concentrations of Lonicera japonica decoction all inhibited toe edema in rats to some extents, the edema was the mildest in the Lonicera japonica decoction high-dose group, which had the strongest inhibitory effect on the development of inflammation, the Lonicera japonica decoction showed certain dose-effect relationship with toe edema in rats. In the rat body temperature control experiment, while body temperature of rats in the blank group had already risen, other groups were still able to lower the body temperature of rats under the action of test drugs. The severity of ear edema in mice in the blank control group was obvious, with increased thickness which showed significant difference between left and right ears. Under test doses, three Lonicera japonica decoction groups all inhibited xylene-induced ear edema in mice. Lonicera japonica has an anti-upper respiratory tract infection action in children.
Highlights
Lonicera japonica is the dried bud or the flower of initial blooming of Lonicera japonica Thunb. in the family Caprifoliaceae, it is sweet in taste, cold in nature, and has the actions of clearing away heat and toxic materials and relieving wind-heat, which is mainly used in the treatment of carbuncle, furunculosis, pharyngitis, erysipelas, bloody flux, common wind-heat cold, febrile disease, fever, etc.[1]
Effect of Lonicera japonica decoction on body temperature in rats The results revealed that compared with the blank control group, the aspirin group and three dose groups of Lonicera japonica decoction could all lower the body temperature in rats, 3 h measurement results showed that the body temperature of rats in the blank group had already risen, while other groups were still able to lower the body temperature of rats under the action of test drugs. 4 h later, body temperature of rats in each group all went up, yet the elevation of body temperature was the fastest in the blank control group, indicating that compared with the blank control group, Lonicera japonica decoction could effectively reduce the body temperature of rats, this had an antipyretic effect
The results showed that compared with the control group, the cure rate and average course of treatment were similar in the 143 cases of children who have taken Lonicera japonica decoction, suggesting significant therapeutic effect of Lonicera japonica decoction on upper respiratory tract infection in children
Summary
Lonicera japonica is the dried bud or the flower of initial blooming of Lonicera japonica Thunb. in the family Caprifoliaceae, it is sweet in taste, cold in nature, and has the actions of clearing away heat and toxic materials and relieving wind-heat, which is mainly used in the treatment of carbuncle, furunculosis, pharyngitis, erysipelas, bloody flux, common wind-heat cold, febrile disease, fever, etc.[1]. Lonicera japonica has been studied extensively by scholars at home and abroad, a number of compounds have been isolated from it, which mainly include organic acids and flavonoids. Objective: To study the active constituents in Lonicera japonica and the mechanism of their anti-upper respiratory tract infection action in children. Methods: Compounds were identified by chromatographic methods, and the mechanism of anti-pediatric upper respiratory tract infection action of Lonicera japonica decoction was studied using experimental animals. Three Lonicera japonica decoction groups all inhibited xylene-induced ear edema in mice. Conclusion: Lonicera japonica has an anti-upper respiratory tract infection action in children. Study on the isolation of active constituents in Lonicera japonica and the mechanism of their anti-upper respiratory tract infection action in children.
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