Study on the inspection and significance of serum soluble interleukin- 2 receptor and interleukin- 6 level in bile after liver transplantation

Abstract

Objective To inspect the expression of serum soluble interleukin- 2 receptor(sIL- 2R) and interleukin- 6(IL- 6)in bile after liver transplantation and to discuss clinical inspection significance of sIL- 2R and IL- 6 after liver transplantation. Methods From December 2012 to February 2014, we selected 69 patients with end- stage liver disease as research subjects after liver transplantation in our hospital.They were divided into 2 groups according to postoperative acute rejection, the patients with postoperative acute rejection group,n= 36, none acute rejection group,n= 33.The sIL- 2R and IL- 6 levels were detected by using sandwich enzyme- linked immunosorbent assay, the expression differences were compared between the two groups. Results There were no significant differences in the expressions of bile IL- 6 and sIL- 2R on the first day after transplantation(P> 0.05);Serum sIL- 2R was(471.82±66.46)pmol/L and bile IL- 6 was (621.81±76.92)pmol/L 48 hours before acute rejection in observation group.When they were diagnosed, the serum sIL- 2R was(721.96±68.53)pmol/L and bile IL- 6 was(858.71±89.52) pmol/L, they were significantly higher than the control group(P 0.05). Conclusion There was close relationship between SIL- 2R, bile IL- 6 and acute rejection after liver transplantation.It was expected to be the sensitivity and specificity indexes in the diagnosis of acute rejection and evaluation of curative effect. Key words: Liver transplantation; Acute rejection; Soluble interleukin- 2 receptor; Interleukin- 6