Study on the influence of the autonomic nerve system in regard to systemic disease caused by experimentally prolonged sensitization

Abstract

To study on the influence of the autonomic nerve system as regards the raising of systemic disease by focal infection, an experiment on rabbits was conducted as follows.A comparative study was histologically, made in the kidney, heart, liver, spleen and adrenal glands, what influence the autonomic nerve irregularity, added at the same time as the reinjection of antigen substance, has upon raising allergic disease in the distant organ and also to investigate the operation of the autonomic nerve system focal infectional systemic diseas, to make use of rabbits which had been subjected to prolonged sensitization injected the streptococcus to aseptic abscess.Antigen-antibody-reaction did not lead by itself to organic pathologic alteration of the organ, and only a swelling and hyperaemia of the glomerule at the kidney was observed, but slight degenerative signs were found in the rabbits bred in. 0-4°C.No purposeful result was obtained in the group injected with medicine to act on the general autonomic nerve at the same time as the antigen reinjection.In the group injected with crotonoil into the tissue of the soft palate before the antigen reinjection to the sensitized rabbits, a remarkable reactive and organic change was noted on all organs that were more intense than group of 1) crotonoil injection, 2) prolonged sensitization and crotonoil injection, 3) crotonoil injection and antibody injection. On the kidney, swelling, hyperaemia and degeneration were appeared in the glomerule and the tubule, and these changes were became worse by the progressing of the date. In the cases proceeded 12 days after the injection of the antigen, atrophic collapse of the glomerule, diffus intensitive degeneration of the tubular epithelial layer and degeneration or disappear of the nucleus partially. That may be explained by the fact the antibody of the organ, acquired by prolonged sensitization, reacted with the reinjected antigen, and the crotonil injective stimulus promoted the raise of organic pathologic alteration.For that reason, the disease raising factor of the autonomic nerve was inferred and the accele-ration of capillary reactivity, caused by irritation of the direct autonomic nerve stimulus, constitute the required condition for raising the allergic alteration of organs with reticuloendothelial hypofunction and etc., and was described about the importance of chronic tonsillitis on focal infection in the same causes.