Abstract
Objective To analyze the genotype genetic characteristics of HLA-DQB1 locus in Chinese Han healthy population. Methods HLA-DQB1 loci of 529 unrelated healthy Chinese Han individuals were analyzed by polymerase chain reaction sequence-based typing (PCR-SBT). Results Eighteen HLA-DQB1alleles and twelve ambiguity ambiguous typing combinations were detected in 529 Chinese Han healthy individuals. HLA-DQB1 * 03:01 (23. 16%), DQB1 * 03:03 (15. 88%), DQB1 * 06:01 (11.63%) and DQB1 * 05:02 (11.15%) alleles were the most common alleles in Chinese Han healthy population. DQB1 *03:01-DQB1 * 03:03 (9. 64%), DQB1 * 03:01-DQB1 * 06:01 (6. 99%), DQB1 * 03:01-DQB1 * 03:01(4. 54 %) genotypes were the most common genotypes. We also detected a rare HLA-DQB1 * 03:01-DQB1* 06:20 genotype with the frequency of 0. 19%. Conclusion The results showed the characteristics of HLA-DQB1 genotype genetic, and the data of HLA-DQB1 genotype distribution provided more useful information in disease association studies and transplants. We should continue to attach importance to the new ambiguity ambiguous typing combinations and distinguish the genotype of them. Key words: human leukocyte antigen; genotype; Chinese Han; sequence-based typing
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