Study on the function and structure of blood vessels of the secondary nodules in lymph node.

Abstract

By means of the stereographic reconstruction technique, the distribution and arrangement of blood vessels in the lymphatic nodules, especially in the secondary nodules, of human and several species of experimental mammary animals were studied. As a result, it was shown that although the development of blood vessels in the secondary nodules varied with the degrees of maturation of the nodules and with the species of animals, the vascular distribution and arrangement of the lymphatic nodules were fundamentally identical among these subjects. The arterial system of the lymphatic nodules was divided into two groups; the secondary nodule arterioles and the mantle zone arterioles. Electron microscopically, the secondary nodule arterioles revealed the ultrastructure of meta‐arterioles or precapillary arterioles. For the examination of the filtrating capacity of arterioles, various perfusion experiments were carried out by intra‐arterial injection using various kinds of fluids. Transudation was scarcely demonstrated in the secondary nodule arterioles, and it was also noted that the capillaries and postcapillary venules developing fairly well in the mantle zone and its vicinity played an important role in plasma tansudation in lymph nodes.