Study on the Extraction Kinetics of Ketoconazole with Hydroxypropyl-β-Cyclodextrin as a Selector

Abstract

This paper reports on the kinetics of extraction of ketoconazole enantiomers in a Lewis cell, which accompanies by an inclusion reaction. The mass transfer model of the extraction process is established based on the homogeneous reaction mechanism and two-film theory. Factors such as stirring speed, phase contact area, and ketoconazole concentration are separately investigated. The obtained data show the inclusion reaction is a fast reaction. The reactions have been found to be first order for ketoconazole enantiomers and second order for hydroxypropyl-β-cyclodextrin with forward rate constants of 1.716 × 10−3 m6/(mol2·s) for (−)-ketoconazole and 2.067 × 10−3 m6/(mol2·s) for (+)-ketoconazole.