Abstract
Objective To investigate whether the expression of metal matrix protease-9 (MMP-9) changes with altitude in severe acute pancreatitis (SAP) lung injury by establishing SAP model in rats. The related indexes of pancreas and lung injury and MMP-9 were measured. Methods 280 SPF male Wistar rats were randomly assigned to different altitude groups to establish SAP model , then the serum amylase (AMY) content of each group were detected. The degree of pancreatic injury and pancreatic pathological score were observed under light microscope. The expression level of MMP-9 in lung tissues was measured and analyzed by statistical methods. Results ⑴ At the same altitude, the expression of MMP-9 in each time group increased with time, with statistically significant difference (P<0.05). ⑵ AMY value, pathological score of pancreas and expression of MMP-9 in lung tissue increased with the altitude in the same time group at different altitudes, with statistically significant difference (P<0.05). Conclusions The higher the altitude, the more severe the damage of SAP and lung, and the higher the expression level of MMP-9. Key words: Altitude; Pancreatitis, acute necrotizing; Lung injury, acute; Matrix metalloproteinase 9; Rats
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