Abstract
ABSTRACT The lack of effective treatment for CRPC is the leading cause of death in prostate cancer patients. However, CRPC exhibits high immunoglobulin (Ig) expression. Ig, one of the most important immune molecules, is a unique product of B lymphocytes and plays an important role in immune defence. The expression of IgG in malignant tumour tissues is positively correlated with the degree of tumour malignancy, and IgG promotes the proliferation and metastasis of tumour cells. A retrospective analysis of immunohistochemical pathological tissue sections collected from 50 patients with prostate cancer (PC) and 40 patients with prostatic hyperplasia from Yichun City People’s Hospital between May 2010 and May 2014 was conducted. The experimental group had an average age of 70.8 ± 2.7 years (58˜86 years old) and included 12 patients with low Ig expression and 38 with high Ig expression. The survival time of the former group was significantly longer than that of the latter group. In vitro, the expression of IgG protein and mRNA in PC3 cells was detected by Western blotting and RT-PCR. IgG expression was knocked down via small interfering RNA (siRNA), and the migration and invasion abilities of PC3 cells were assessed using a Transwell assay. Positive expression of tumour-derived IgG in prostate cancer can indicate poor prognosis of patients with prostate cancer, and high IgG expression promotes the invasion and metastasis of prostate cancer. Thus, IgG may become a therapeutic target in prostate cancer.
Highlights
According to the classical immunological theory, immunoglobulins (Igs) are a unique product of B lymphocytes
RELATIONSHIP BETWEEN IGG EXPRESSION IN PROSTATE CANCER TISSUES AND PATHOLOGICAL GRADE The expression of Immunoglobulin G (IgG) increased as the Gleason score describing prostate cancer pathology increased
castration-resistant prostate cancer (CRPC) has been the focus of prostate cancer research
Summary
According to the classical immunological theory, immunoglobulins (Igs) are a unique product of B lymphocytes. It is believed that the prominent feature of non-B Ig is its high expression in malignant transformed cells; in addition, its expression level is closely related to poor tumour differentiation and prognosis. It promotes tumour invasion and metastasis [6,7,8]. IgG expression in prostate cancer and corresponding normal prostate tissues was assessed by immunohistochemistry (IHC), and its relationship with tumour proliferation and invasion was confirmed by in vitro experiments. The influence of IgG on the progression of prostate cancer was discussed from an immunological perspective
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