Study on the event-related potentials P300 of schizophrenic patients with aggressive or violent behaviors

Abstract

Objective To explore the electrophysiological mechanisms of the schizophrenic patients with aggressive or violent behaviors. Methods Access the aggressive behaviors of schizophrenic patients being treated in hospitals or clinics with the revised MOAS in accordance with the ICD-10 diagnostic criteria, and sort the qualified patients into two groups: the group of aggressive or violent schizophrenia (Aggressive Group, n=70) and the group of non-aggressive or non-violent schizophrenia (Non-Aggressive Group, n=65); 60 age- and gender-matched healthy people were collected as Healthy Group. P300 tests were carried out on patients in these three groups with the MEB-9200 Nicolet Bravo Instrument by the Nihon Kohden Corporation. Results (1) Latency P3a of the Aggressive Group on Cz point exceeded that of the Non-Aggressive Group (P=0.01), and that of the Non-Aggressive Group exceeded that of the Healthy Group. All these disparities were of statistical significance (P<0.01). Latency P3a of the Aggressive Group on Fz point exceeds that of the Non-Aggressive Group, and that of the Non-Aggressive Group exceeded that of Healthy Group. All these disparities are also of statistical significance(P<0.01). (2)N2′ amplitude of the Aggressive Group on Cz point was higher than those of the Non-Aggressive Group and the Healthy Group. This disparity was of statistical significance(P<0.05) and the disparity between the Non-Aggressive Group and the Healthy Group did not have statistical significance(P=0.985). Conclusion Characteristic electrophysiological changes exist in the event-related potentials P300 of schizophrenic patients with aggressive or violent behaviors. Key words: Schizophrenia; Aggressive or violent behaviors; Event-related potentials