Study on the effectiveness of transfusion program in dengue patients receiving platelet transfusion

Abstract

Aims: Dengue infection is a global health problem affecting an estimated population of 50–100 millions every year. Thrombocytopenia is an essential diagnostic criteria. Platelet transfusion is given in those patients who have haemorrhagic manifestations along with thrombocytopenia. The aim of the study was to know the effectiveness of platelet transfusion in dengue patients. Methods: The study was conducted during the epidemic of dengue fever from July 2011 to October 2011. Serologically confirmed dengue cases were included in the study. Results: Two hundred thirty two patients were positive for dengue serological tests of which 195 (84.2%), 35 (15%), 2 (0.8%) were DF, DHF DSS respectively. One hundred eighty two (78.4%) patients received platelet transfusion. One hundred eighteen (51%) cases received single unit of platelet transfusion though platelet count was between 0.2–1.0x10x105/mm3. Sixty four (27.5%) patients who had platelet count <0.2x105/mm3 received multiple platelet transfusions. The patient who received multiple platelet transfusion of 10–12 units showed post transfusion increment of >0.5x105/mm3 and they were discharged after 5–6 days of hospitalization. Conclusions: This study suggests that 51% platelet transfusions are inappropriate and it is more effective when it is given to patients with platelet count <0.2x105/mm3. Platelet transfusion practice should be based upon platelet count and haemorrhagic manifestations as this decreases hospitalization of the patients and complications of dengue.