Study on the effective dose 50 of sufentanil blunting responses to double-lumen endotracheal intubation in elderly patients

Abstract

Objective To determine the effective dose 50 (ED50) of sufentanil blunting the responses to double-lumen endotracheal intubation under propofol in elderly patients. Methods A retrospective analysis was conducted on patients aged 65-78 years with body mass index 90 bpm within 3 min after tracheal intubation.The ED50(95% confidence interval) of sufentanil blunting the responses to double-lumen endotracheal intubation was calculated. Results The ED50(95%confidence interval) of sufentanil blunting the responses to double-lumen endotracheal intubation in elderly patients was 0.331 μg/kg, and the 95%confidence interval was 0.246-0.409 μg/kg. Conclusions Under propofol to maintain BIS 45-55, the ED50 of sufentanil blunting the responses to double-lumen endotracheal intubation in elderly patients was 0.331 μg/kg. Key words: Sufentanil; Intubation, intratracheal; Dose-response relationship, drug