Study on the Effect of Sample Temperature on the Uniaxial Compressive Mechanical Properties of the Brain Tissue.

Xiaopeng Deng,Guanjun Zhang ,Xiaojun Jia ,Fengjiao Guan

doi:10.1155/2021/9986395

Abstract

Craniocerebral injury has been a research focus in the field of injury biomechanics. Although experimental endeavors have made certain progress in characterizing the material behavior of the brain, the temperature dependency of brain mechanics appears to be inconclusive thus far. To partially address this knowledge gap, the current study measured the brain material behavior via unconstrained uniaxial compression tests under low strain rate (0.0083 s−1) and high strain rate (0.83 s−1) at four different sample temperatures (13°C, 20°C, 27°C, and 37°C). Each group has 9~12 samples. One-way analysis of variance method was used to study the influence of sample temperature on engineering stress. The results show that the effect of sample temperature on the mechanical properties of brain tissue is significant under the high strain rate, especially at low temperature (13°C), in which the hardening of the brain tissue is very obvious. At the low strain rate, no temperature dependency of brain mechanics is noted. Therefore, the current results highlight that the temperature of the brain sample should be ensured to be in accordance with the living subject when studying the biomechanical response of living tissue.

Highlights

Craniocerebral injury is one of the common injuries and major causes of death in traffic accidents [1]
The results of this study showed that there is no significant difference in the engineering stress of brain tissue at the sample temperature of 20-37°C regardless of low strain rate (0.0083 s-1) and high strain rate (0.83 s-1)
In this study, when the sample temperature was 13°C, the engineering stress increased significantly (p = 0:000) with the decrease of temperature under the condition of high strain rate, which was consistent with the results obtained by Hrapko et al The experimental results in this study showed that the sample temperature had no significant effect on the compression response of brain tissue at low strain rate, but it had a significant effect at high strain rate

Summary

Introduction

Craniocerebral injury is one of the common injuries and major causes of death in traffic accidents [1]. Compared to biomechanical experiments that can be either hardly possible to perform due to moral reasons or extremely difficult associated with technical challenges and enormous expenses [6,7,8,9,10,11,12], the finite element simulation method is a instrumental approach to evaluate the mechanical response of biological tissues under various load conditions and further uncover the mechanism of craniocerebral injury [4, 13, 14]. The biofidelity of the finite element model relies on accurate material constitutive parameters. It is of great significance to study the factors affecting the constitutive parameters of brain tissue materials

Methods

Discussion

Conclusion