Abstract
This research aimed to evaluate the antihepatic fibrosis effect and explore the mechanism of Qiwei Qinggan Powder (QGS-7) in vivo and in vitro. Carbon tetrachloride (CCl4)-treated rats and hepatic stellate cells (HSCs) were used. QGS-7 treatment significantly improved the liver function of rats as indicated by decreased serum enzymatic activities of alanine aminotransferase, aspartate transaminase, and alkaline phosphatase. Meanwhile, the hydroxyproline of liver was significantly decreased. Histopathological results indicated that QGS-7 alleviated liver damage and reduced the formation of fibrosis septa. Moreover, QGS-7 significantly attenuated expressions of Alpha smooth muscle actin, Collagen I, Janus kinase 2 (JAK2), phosphorylation-JAK2, signal transducer and activator of transcription 3 (STAT3), phosphorylation-STAT3 in the rat hepatic fibrosis model. QGS-7 inhibited HSC proliferation and promoted it apoptosis. QGS-7 may affect hepatic fibrosis through JAK2/STAT3 signaling pathway so as to play an antihepatic fibrosis role.
Highlights
To study the anti-hepatic fibrosis effect and explore the mechanism ofQiwei Qinggan Powder (QGS-7) in vivo and in vitro
In order to study the anti-fibrosis effect of QGS-7, we first studied the therapeutic effect of QGS-7 on CCl4 induced hepatic fibrosis in rats
The results showed that QGS-7 could significantly inhibit the expression of Janus kinase 2 (JAK2) and STAT3
Summary
To study the anti-hepatic fibrosis effect and explore the mechanism ofQiwei Qinggan Powder (QGS-7) in vivo and in vitro. To study the anti-hepatic fibrosis effect and explore the mechanism of. Hepatic fibrosis is an important health problem in the world. Hepatic fibrosis is mainly related to chronic hepatitis B or C infection, alcoholic steatohepatitis, nonalcoholic steatohepatitis and biliary diseases [2]. With the progress of fibrosis, cirrhosis will occur, and even develop into HCC [3,4]. It is urgent to study the therapeutic drugs and mechanism of hepatic fibrosis. Mongolian medicine is an important part of traditional Chinese medicine. It is the cream of traditional culture. It has unique theoretical system, special curative effect for many diseases, and great potential for development
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