Abstract
While conducting studies on the induction of ovulation in anovulation, and the stimulation of luteal function in luteal insufficiency, with the hyperpotent analog of LH-RH, we found that the LH-RH analog was effective in inhibiting the gonadal functions. We therefore started studies on the possible use of the analog in the termination of early pregnancy and to investigate its mechanism of action. As a trial agent, we used [des-gly10][pro9-ethylamide]-LH-RH or D-leu6-LH-RH-EA. Low levels of urinary hCG were measured by the Hi-Gonavis method.
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