Study on the diagnosis of idiopathic rhinitis by cold dry air provocation

Abstract

Objective:This study aimed to compare the nasal response of cold dry air（CDA） provocation in patients with idiopathic rhinitis（IR） and healthy individuals, and further assess its ability in diagnosing IR. Method:CDA provocation was performed among 15 healthy volunteers and 17 IR patients from Beijing Tongren Hospital Outpatient Department. Nasal symptom scores, total nasal volume（TNV）, total nasal resistance（TNR） and minimal cross-sectional area（MCA） were checked before and after the provocation. Logistic regression analysis and Receiver Operating Characteristic（ROC） curves were used in data evaluation. Result:Subjects in the IR group showed significantly larger changes after CDA provocation in total nasal symptom score（TNSS）, total nasal resistance（TNR）, minimal cross-sectional area（MCA） and total nasal volume（TNV）, compared with healthy volunteers. We built a predictive model for IR, Y=0.394×ΔTNSS-0.061 ×ΔTNV（%）+0.014×ΔTNV（%） -2.318, whose area under curve was 0.919 based on multi-factor logistic regression and ROC curve. According to the Youden index, the cut-off criteria was set to be Y >0.49, when its sensitivity and specificity were 82.4% and 84.6%, respectively. Conclusion:Aggravated nasal symptoms and decreased nasal ventilation could be seen after CDA provocation in the IR population. The CDA provocation provides a possible method for assisting the diagnosis of IR, and we'll expand the sample size in future research to verify its clinical application value.