Study on the detection of tumor markers in the differential value of benign and malignant hydrothorax and ascites

Abstract

Objective To study the clinical value of tumor markers in differentiating benign and malignant pleural effusion and ascites. Methods To select 169 cases with malignant pleural effusion and ascites as malignant group, and 146 cases with benign ascites as benign group.The levels of pleural fluid carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9) in the two groups were evaluated. And evaluate the method of diagnostic markers of benign and malignant hydrothorax and ascites on the tumor. Result CEA of malignant group was(139.7±56.4)ng/mL, AFP was (189.2 ±45.2) ng/mL, CA125 was(314.7±86.2)U/mL and CA19-9 was(158.5± 24.2)U/mL.The concentration is higher than the benign group, the difference was statistically significant (P<0.05); then CEA, AFP, CA125 and CA19-9 under the curve were 0.811, 0.547, 0.715, 0.769.The corresponding diagnostic levels were 5.6 ng/mL, 63.7 ng/mL, 38.9 U/mL, 30.4 U/mL.So AFP was not suitable for the diagnosis of malignant pleural effusion and ascites for the low area under the ROC curve.CEA was the best indicator for evaluation of tumor in three tumor markers, and the sensitivity was 75.7%, specificity was 88.6%.CEA, CA125 and CA19-9 combined detection effect was better in the combined detection, the sensitivity was 80.5% and specificity was 94%. Conclusion Combined detection of tumor markers have important clinical application value of the nature of identification of hydrothorax and ascites. Key words: Tumor marker; Pleural effusion and ascites; Malignant tumor; Benign