Study on the correlation of bone turnover makers and bone mineral density in postmenopausal women

Abstract

Objective To investigate the correlation of bone turnover makers and bone mineral density (BMD) in postmenopausal women. Methods BMD value of the lumbar was measured by dual-energy X-ray absorption meter. 109 postmenopausal women were divided into non- osteoporosis group (NOP group), osteopenia group (OP1 group), and osteoporosis group (OP2 group) according to the BMD level. The serum bone turnover markers including osteocalcin (OC), N-terminal propeptide of type Ⅰ procollagen (PINP), β collagen specific sequences (β-CTX), 25 hydroxy vitamin D (VitD-T), and parathyroid hormone (PTH) were detected by electrochemical luminescence method. Results With the aggravation of osteoporosis, the value of BMD gradually decreased, while the age increased. There were no statistically significant differences in serum levels of OC, PINP, β-CTX, and PTH among the three groups (P>0.05). Conclusions No significant correlation has been found between the bone turnover makers and BMD in patients with postmenopausal osteoporosis. The serum levels of OC, PINP, β-CTX, and PTH only reflect the level of bone remodeling in postmenopausal women, while have limited value for diagnosis of osteoporosis. Key words: Bone mineral density; Bone turnover makers; Postmenopausal; Osteoporosis