Study on the Correlation between the Levels of HtrA3 and TGF-β2 in Late Pregnancy and Preeclampsia.

Wenying Huang,Shuxuan Zhang,Kalidoss Rajakani

doi:10.1155/2022/4453646

Wenying Huang, Shuxuan Zhang + Show 1 more

Open Access

https://doi.org/10.1155/2022/4453646

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Abstract

Preeclampsia (PE) is a common and proprietary complication during pregnancy. The correlation was found between the levels of HtrA3 and TGF-β 2 and preeclampsia (PE). This study aimed to detect the HtrA3 and TGF-β2 in different parts of the third trimester (maternal serum, placenta). The 102 pregnant women who were eligible for enrollment in the obstetric examination at Tengzhou Maternity and Child Health Hospital from June 2020 to December 2020 were selected as the research objects. 28 cases diagnosed with PE were set up as the observation group 1, and 24 cases diagnosed with severe PE were set up as the observation group 2. Select 50 normal pregnant women as the control group and research the expressions of HtrA3 and TGF-β2 in maternal blood and placental tissues of patients with PE. ELISA was used to measure the concentration of HtrA3 and TGF-β2 in maternal blood. The distribution of HtrA3 and TGF-β2 in the placenta was observed by immunohistochemical techniques (IHC) and mean optical density value (MOD). S/D was measured by using color Doppler ultrasonic. The concentration of HtrA3 and TGF-β2 in the maternal blood and placenta tissue was higher in severe PE compared with PE and normotensive pregnancy, respectively (P < 0.05). There is a negative correlation between the level of HtrA3 and TGF-β2 and the birthweight of newborns both in maternal plasma and placenta tissue in preeclampsia and positive correlation between HtrA3 and TGF-β2 levels and S/D. HtrA3 and TGF-β2 may correlate with severity of PE and their neonatal adverse outcomes.

Highlights

Preeclampsia (PE) refers to new hypertension, proteinuria, or multiple organ damage that cannot be explained by other diseases after 20 weeks of pregnancy
When trophoblast cells are planted and enter the myometrium to promote the formation of the placenta, HtrA3 can inhibit this process by regulating TGF-β signaling and has a certain relationship with the pathogenesis of preeclampsia
TGF-β can participate in the regulation of the severity of preeclampsia by influencing the transformation of the endometrium to decidua, controlling the penetration of trophoblasts into the myometrium, and inhibiting the formation of placenta

Summary

Introduction

Preeclampsia (PE) refers to new hypertension, proteinuria, or multiple organ damage that cannot be explained by other diseases after 20 weeks of pregnancy. The pathogenesis has not been studied clearly, but most experts believe that one of the reasons for the onset of preeclampsia is insufficient trophoblast invasion [2]. When trophoblast cells are planted and enter the myometrium to promote the formation of the placenta, HtrA3 can inhibit this process by regulating TGF-β signaling and has a certain relationship with the pathogenesis of preeclampsia. The research on HtrA3 and preeclampsia mainly focuses on the early and second trimesters. Whether the expression of HtrA3 in various detection methods in the third trimester is related to preeclampsia and neonatal outcomes has not been reported yet. TGF-β can participate in the regulation of the severity of preeclampsia by influencing the transformation of the endometrium to decidua, controlling the penetration of trophoblasts into the myometrium, and inhibiting the formation of placenta.

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