Study on the correlation between the level of bioactive factors in the blood and severity of diabetic retinopathy

Abstract

Objective To analyse the correlation between the level of related bioactive factors in the blood and severity of diabetic retinopathy(DR). Methods The data of 100 patients with DR admitted in Traditional Chinese Medical Hospital of Huangdao District from Jun.2016 to Dec.2018 were selected in the prospective study. There were 50 cases of non-proliferative DR and 50 cases of proliferative DR. At the same time, 50 non-DR diabetic patients and 50 healthy people were selected as the healthy control group. The levels of Apelin, TNFR and MK in the blood were detected and the correlation between the level of bioactive factors and severity of the disease was analyzed. Results The difference in levels of Apelin, TNFR and Midkine in the blood were statistically significant among the four groups (P<0.05), and the levels of Apelin, TNFR and Midkine were the highest in the proliferative DR group; the levels of Apelin, TNFR and Midkine were positively correlated with the severity of DR patients (P<0.05). The specificity of DR and the area under the receiver operating characteristic curve were significantly higher than those of Apelin, TNFR and Midkine alone (P<0.05). Conclusion The levels of Apelin, TNFR and Midkine increase with the aggravation of DR. The combined detection of Apelin, TNFR and Midkine can help to improve the diagnostic value of DR. Key words: Apelin; TNFR; Midkine; Diabetic retinopathy; Severity