Abstract
Objective: To explore the relationship between serum ferritin (SF) and gestational diabetes mellitus (GDM), for providing new ideas to the prevention and treatment of GDM. Methods: All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of GDM, 72 patients with GDM were selected as the case group and 72 normal pregnant women were randomly selected as the control group. Fasting venous blood was drawn from all subjects during the first trimester of pregnancy (11-13 weeks) and the second trimester of pregnancy (24-28 weeks). Fasting plasma glucose was measured by glucose oxidase assay and the expression level of SF was determined by electrochemical method. The application value of SF in GDM diagnosis was evaluated by ROC curve. Results: The levels of SF in the case group at early and middle stages are 49.6 ± 18.8 (μg/ml) and 39.8 ± 21.5 (μg/ml), which re 39.4 ± 15.2 (μg/ml) and 32.2 ± 17.6 (μg/ml) in the control group. The levels of SF in the case group were higher than those in the control group (p ) at early and middle stages. The curve (AUC) of SF level in the diagnosis of GDM was 0.895, p the Youden index was 0.651 and the optimum threshold was 38.6 ng/ml, with a sensitivity of 97.8% and a specificity of 67.3%. Conclusion: The expression level of SF in early pregnancy is correlated with the occurrence of GDM, which may be an important indicator for the prevention and monitoring of GDM.
Highlights
All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of gestational diabetes mellitus (GDM), 72 patients with GDM were selected as the case group and 72 normal pregnant women were randomly selected as the control group
The gestational diabetes mellitus (GDM) refers to different degrees of hyperglycemia resulting from abnormal glucose tolerance and diabetes during the gestation period, but the glycometabolism is normal before gestation
According to the comparison between the case group and the control group in serum ferritin (SF) expression level of peripheral blood (PB) in different periods of pregnancy, SF of the case group is higher than the control group, indicating statistical difference (p < 0.05)
Summary
The gestational diabetes mellitus (GDM) refers to different degrees of hyperglycemia resulting from abnormal glucose tolerance and diabetes during the gestation period, but the glycometabolism is normal before gestation. Many researchers have indicated that increase of iron element level in serum can result in changes in the blood glucose and have a correlation with insulin resistance [4] [5]. Serum ferritin (SF) is one of the proteins with the highest iron content in the body. It can directly reflect the iron reserves in the body and is a sensitive indicator for evaluating iron deficiency or overload. High SF level is an independent risk factor for T2DM. The serum ferritin (SF) is an important index that reflects the content of iron element in body, while high levels of serum iron significantly increase the risk of GDM [6]. There are few researches about correlation between SF and GDM; we have measured SF expression level at early and middle pregnancy and discussed its correlation with GDM in this research, laying theoretical foundation for early prevention and clinical treatment for GDM
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