Study on the correlation between serum PAPPA level of pregnant women and pregnancy complications

Abstract

Objective To study the correlation between serum pregnancy associated plasma protein A (PAPPA) level of pregnant women and pregnancy complications. Methods From Sep. 2010 to Dec. 2016, 4 920 Down syndrome screening cases in our hospital were selected as observation group, and during the same period 2 350 normal pregnant women were selected as control group. All the pregnant women were followed up and their data were collected and analyzed, and the serum PAPPA levels in the two groups were compared. Results 3 400 cases in the observation group were successfully followed up, including 2 145 cases with normal pregnancy and prognosis (63.09%), 71 cases with spontaneous abortion or termination of pregnancy (2.09%), 65 cases with threatened abortion (1.91%), 48 cases with pregnancy induced hypertension syndrome (1.41%), 99 cases with gestational diabetes (2.91%), and 156 cases with gestational impaired glucose tolerance (4.59%). 1 700 cases in the control group were successfully followed up. The statistical analysis showed that the serum PAPPA level in the observation group was significantly lower than that in the control group at different gestational weeks (P<0.05). The lower the serum PAPPA level was, the higher the incidences of spontaneous abortion or termination of pregnancy, threatened abortion, pregnancy induced hypertension syndrome, gestational diabetes, and gestational impaired glucose tolerance were. Conclusion The low serum PAPPA level of pregnant women can promote the occurrence of pregnancy complications, such as spontaneous abortion, threatened abortion, pregnancy induced hypertension syndrome, and gestational diabetes. Key words: Pregnant women; Serum PAPPA; Pregnancy complications