Study on the correlation between serum adiponectin, Apelin and infant vascular endothelial growth factor receptor-1 level and children’s body mass in patients with gestational diabetes

Abstract

Objective Through the determination of pregnancy gestational diabetes mellitus (GDM) lactating women colostrum and 90 day mature milk adiponectin (Adiponectin), Apelin, baby vascular endothelial growth factor-1 (VEGF-R1) receptor levels, to detect the correlation between maternal serum levels of lipid and glucose metabolism abnormality and children’s body mass. Methods Prospective randomized controlled trials were used from December 2014 to June 2015, GDM pregnant women and their newborns for GDM group (20 pairs) were selected; in addition to select obstetrical period singleton term delivery, and no pregnancy complications of healthy pregnant women and newborns as control group (n=25). The changes of Adiponectin and apelin levels in maternal colostrum and mature milk were detected, and the levels of VEGF-R1 in umbilical cord blood were compared, and the correlation between Adiponectin, apelin, VEGF-R1 and the quality of children’s body was analyzed. Results In GDM group , the Adiponectin levels in colostrum and mature milk were significant lower than those of the control group (P 0.05). Adiponectin and neonatal umbilical cord blood VEGF-R1 were positively correlated with neonatal body mass in GDM breast feeding women. However, Apelin was not related to the quality of newborn babies in the breast milk of GDM during lactation. Conclusions In pregnant women with abnormal glucose metabolism, obesity in pregnancy and prenatal has remarkable effects on their children’s body mass, and its level is closely correlated with Adiponectin, apelin in the mother’s milk and baby’s own VEGF-R1. Key words: Gestational diabetes mellitus; Adiponectin; Apelin; Vascular endothelial growth factor-1; Body mass in children