Study on the correlation between insulin-like growth factor-I and neuron-specific enolase in cerebrospinal fluid of children with CNS infection

Abstract

Objective To explore the correlation between insulin-like growth factor-I （IGF-I） and neuron-specific enolase （NSE） in cerebrospinal fluid （CSF） of children with CNS infection. Methods 90 cases were recruited in the study, among which 30 cases were patients with bacterial, meningitis （BM）, 30 cases with viral encephalitis （VM） and the rest belonged to contrast groups. CSF of all 90 cases was collected during the period from 24 to 48 hours after admission. IGF-I and NSE in CSF were measured by FJ-2008 PS γ immunocount instrument. Results Both BM and VM group had a significant difference in IGF-I and NSE as compared with control group （P 〈 0.01）, but there was no significant difference between BM and VM group （P〉0.05）. IGF-I and NSE in CSF of BM and VM group were not correlated with each other. However, IGF-I and NSE showed positive correlation in 15 patients with conscious disturbance （r = 0.94, P 〈 0.01）. Conclusion Our study showed that IGF-I and NSE in CSF of patients with CNS infection increased greatly. IGF-I and NSE in CSF of critically ill children were correlated positively. It suggests that IGF-I play a certain role in protecting and repairing central nervous system. Key words: Central nervous system; Infection; Cerebrospinal fluid; Insulin-like growth factor-I; Neuron-specific enolase