Study on the Correlation between Cholecystectomy and Nonalcoholic Fatty Liver Disease in Type 2 Diabetes

Abstract

Objective: To study the relationship between nonalcoholic fatty liver disease and cholecystectomy in patients with type 2 diabetes mellitus (DM). Methods: From January 2011 to December 2014 3970 cases of hospitalized patients with type 2 diabetes, divided 2 groups, without cholecystectomy group (3435 cases) and cholecystectomy group (535 cases), clinical data and biochemical indexes of the two groups were compared including liver function, renal function, blood lipid, glycosylated hemoglobin, glycated albumin and blood routine, CRP data. Results: The prevalence of NAFLD in the cholecystectomy group was higher than that in the without cholecystectomy group(60.9% vs. 46.1%), and the difference was significant (P<0.001). The levels of TG and BMI in the cholecystectomy group were higher than those in the without cholecystectomy group (P<0.05). The risk factors of NAFLD two classification logistic regression analysis of risk factors, there exists in the model of 5 variables, including history of cholecystectomy (P<0.001, OR=1.896), sex (P<0.001, OR=0.584), waist circumference (P <0.001, OR = 1.047), TG (P <0.001, OR= 2.058),BMI(P<0.05,OR=1.173) were independently correlated with NAFLD. Conclusion: Cholecystectomy is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus. Disclosure L. Ye: None. H. Chen: None.