Study on the Clinical Anesthesia of Esketamine Combined with Propofol in Endoscopic Retrograde Cholangiopancreatography

Abstract

Objective: To observe the safety and effectiveness of the intravenous anesthesia of Esketamine and propofol in endoscopic retrograde cholangiopancreatography (ERCP). Method: 80 patients undergoing ERCP in our hospital were selected, aged 40-65 years old, the body mass index (BMI) 20-24, ASAI-II. They were divided into control group (40 cases) and observation group (40 cases) according to the random digital table. Patients in the control group received intravenous anesthesia by Dezocine combined with propofol, and patients in the observation group received intravenous anesthesia by Esketamine combined with Propofol. The patient's heart rate (HR), non-invasive systolic pressure (SBP), diastolic blood pressure (DBP) and pulse oxygen saturation (SPO2) at pre-anesthesia induction time (T0), induction immediate time (T1), the gastroscope immediate time (T2), the before-end time (T3), recovery immediate time (T4); recovery time and total amount of propofol, adverse reactions; the satisfaction of patients, anesthesia doctors and surgeons for the whole process were recorded. Results: There was no significant difference in blood pressure and heart rate difference between the two groups. Compared with the control group, the respiratory inhibition, postoperative dizziness, nausea of patients in Esketamine group decreased (P <0.01), the total use of propofol was less than the control group (P <0.05). The satisfaction of patients, anesthesia doctors and surgeons were superior to the control group (P <0.01). Conclusion: Esketamine combined with propofol for intravenous anesthesia can be safely and efficiently applied to ERCP. In the operation, the patients’ breathing is stable and controllability is good with less postoperative adverse reactions. The satisfaction of patients and physicians is high. Thus, it has high clinical promotion value.