Abstract
Bergenia purpurascens has tonic, haemostatic and anti-tussive actions. Anti-inflammatory and anti-bacterial activities of Bergenia purpurascens have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of Bergenia purpurascens through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects. Experimental models of xylene-induced ear edema in mice, cotton pellet granuloma in rats, and acetic acid-induced peritoneal capillary permeability in mice were used to investigate the anti-inflammatory effect of Bergenia purpurascens; bacteriostatic and bactericidal effects of Bergenia purpurascens extract on Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), and β-lactamase positive Staphylococcus aureus (ESBLs-SA), were observed in vitro. The results show that Bergenia purpurascens extract could markedly inhibit xylene-induced mouse ear edema, cotton pellet granulation tissue hyperplasia, and increased capillary permeability. Bergenia purpurascens extract has an inhibitory effect on SA, MRSA and ESBLs-SA. We conclude that Bergenia purpurascens extract has certain anti-inflammatory and anti-bacterial effects.
Highlights
Yan Bai Cai is the dried rhizome of Bergenia purpurascens
Inhibitory effect of Bergenia purpurascens extract on xylene-induced ear edema in mice
Inhibitory effect of Bergenia purpurascens extract on cotton pellet granuloma in rats The results are shown in Tab. 2, compared with the blank control group, granulomas in the Bergenia purpurascens extract medium- and low-dose groups were decreased, but the differences were not statistically significant (P>0.05); while the granuloma inhibitory effects of Bergenia purpurascens extract high-dose group and indomethacin group were significant, and the differences were statistically significant (P
Summary
Yan Bai Cai is the dried rhizome of Bergenia purpurascens (Hook. F. et Thoms.) Engl. is the genus Bergenia, of the family Saxifragaceae, which is mainly distributed throughout the northwest, central and northeast Yunnan. Is the genus Bergenia, of the family Saxifragaceae, which is mainly distributed throughout the northwest, central and northeast Yunnan. Literature search found that the anti-inflammatory and anti-bacterial activities of Bergenia purpurascens have not been reported so far. SA, MRSA and ESBLs-SA inhibitory activities as well as anti-inflammatory activity of Bergenia purpurascens extract were studied for the first time using K-B method and liquid culture method, providing a scientific basis for the research and development in the fields of food security and pharmaceutical production. Anti-inflammatory and anti-bacterial activities of Bergenia purpurascens have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of Bergenia purpurascens through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects. Conclusion: We conclude that Bergenia purpurascens extract has certain anti-inflammatory and anti-bacterial effects
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
