Study on the ability of 3D gamma analysis and bio-mathematical model in detecting dose changes caused by dose-calculation-grid-size (DCGS)

Han Bai,Xingrao Wu,Jiawen Yan,Feihu Chen,Sijin Zhu,Xuhong Liu

doi:10.1186/s13014-020-01603-6

Abstract

ObjectiveTo explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).Methods17 patients’ plans for cervical cancer were enrolled (Pinnacle TPS, VMAT), and the DCGS was changed from 2.0 mm to 5.0 mm to calculate the planned dose respectively. The dose distribution calculated by DCGS = 2.0 mm as the “reference” data set (RDS), the dose distribution calculated by the rest DCGS as the“measurement”data set (MDS), the 3D gamma passing rates and the (N) TCPs of the all structures under different DCGS were obtained, and then analyze the ability of 3D gamma analysis and (N) TCP model in detecting dose changes and what factors affect this ability.ResultsThe effect of DCGS on planned dose was obvious. When the gamma standard was 1.0 mm, 1.0 and 10.0%, the difference of the results of the DCGS on dose-effect could be detected by 3D gamma analysis (all p value < 0.05). With the decline of the standard, 3D gamma analysis’ ability to detect this difference shows weaker. When the standard was 1.0 mm, 3.0 and 10.0%, the p value of > 0.05 accounted for the majority. With DCGS = 2.0 mm being RDS, ∆gamma-passing-rate presented the same trend with ∆(N) TCPs of all structures except for the femurs only when the 1.0 mm, 1.0 and 10.0% standards were adopted for the 3D gamma analysis.ConclusionsThe 3D gamma analysis and bio-mathematical model can be used to analyze the effect of DCGS on the planned dose. For comparison, the former’s detection ability has a lot to do with the designed standard, and the latter’s capability is related to the parameters and calculated accuracy instrinsically.

Highlights

volumetric modulated arc therapy (VMAT) technology is widely used for the cervical cancer radiotherapy [1,2,3]
These studies on the application have shown that VMAT technology can be used for cervical cancer radiotherapy, and compared with High Dose Rate brachytherapy, VMAT plan achieves significant dose reduction of rectum, bladder and sigmoid, as well as superior homogeneous target coverage compared to brachytherapy plan [4,5,6]
A smaller dose calculation grid size (DCGS) should be chosen for dose calculation in radiotherapy for head and neck tumors to obtain precise doses of small-volume OARs including lens, optic nerve and pituitary, etc., especially important for OARs with strict maximumdose limit [8, 9]

Summary

Introduction

The dose calculation grid size (DCGS) is a basic parameter setting in the design of the plan. A commercial treatment planning system (TPS) will provide various DCGS within a certain range for designers to choose for different needs. The commercial Pinnacle TPS provides DCGS ranging from 1.0 mm to 10.0 mm, and the default DCGS is 4.0 mm [7]. A smaller DCGS should be chosen for dose calculation in radiotherapy for head and neck tumors to obtain precise doses of small-volume OARs including lens, optic nerve and pituitary, etc., especially important for OARs with strict maximumdose limit [8, 9]

Methods

Results

Conclusion