Abstract
Study on synergistic effect of new functionalized Ag nanoparticles for intracellular drug uptake in cancer cells
Highlights
It is well known that cancer is one of the major killers to human health, and its morbidity and mortality is in the upward trend in recent years, early diagnosis and effective treatment is very important
Our results show that the nanocomposites can effectively enhance the accumulation of anticancer drugs into the cancer cells, thereby greatly increasing the intracellular drug concentration in leukemia cells and enhancing the lethal effect on cancer cells
Daunorubicin was purchased from Nanjing pharmacy factory, and stock solutions were freshly prepared by sterilized phosphate buffer solution (PBS) (0.1 molL-1, pH=7.2) and stored in the dark at 4°C
Summary
It is well known that cancer is one of the major killers to human health, and its morbidity and mortality is in the upward trend in recent years, early diagnosis and effective treatment is very important. With the feature of excellent bio-compatibility, Ag NPs play an important role in biomedical applications [15,16,17,18,19]. In this contribution, we have explored the combination of the functionalized Ag nanoparticles with anticancer drugs daunorubicin (DNR) to form a new biocompatible nanocomposite to facilitate the cellular drug uptake in leukemia cells. Our results show that the nanocomposites can effectively enhance the accumulation of anticancer drugs into the cancer cells, thereby greatly increasing the intracellular drug concentration in leukemia cells and enhancing the lethal effect on cancer cells
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