Abstract
Rats of three strains, ACI, Buffalo and Wistar, were treated with 1, 2-dimethylhydrazine (DMH) 20 mg/kg/week, serially for nine weeks and sacrificed at the 6th week after the last injection. In control rats, saline was administered ad libitum. In Wistar rats, the incidence of colon tumors (32/ 50) was significantly higher than that in ACI rats (10/44) and Buffalo rats (8/50) (P <0.005).Both the saline-treated and DMH-treated groups of ACI rats showed a higher peripheral lymphocyte count than those in Buffalo and Wistar rats. There was no strain difference in natural killer cell activity among the saline-treated groups. On the other hand, Wistar rats showed significantly higher natural killer cell activity among the three rat strains after DMH administration. The serum immunosuppressive substance level was high in the tumor-free and colonic tumor-bearing groups of Wistar rats. Thus immunological parameters selected in this study seemed to be insufficient to explain the strain difference in susceptibility to DMH.
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