Study on spectrum-effect relationship between fingerprint of essential oil and of anti-tumor effect from Curcuma kwangsiensis

Abstract

The objective of this study was to investigate the effective component group represented by fingerprint contributed to pharmacodynamics by grey relational analysis, and provide a reference for traditional Chinese medicine quality control and develop evaluation criteria of pharmacodynamics. The fingerprint of essential oil from Curcuma kwangsiensis was established by gas chromatography-mass spectrometry (GC-MS), and the anti-tumor effect of curcuma oil was studied. At the premise of the acquired GC-MS characteristic of fingerprint and pharmacodynamics data to inhibit proliferation of nasopharyngeal carcinoma cell, the relational grade and relational sequence between fingerprint of essential oil and of inhibiting proliferation rate were calculated by grey relational analysis. According to the relational grade, the sequence of contribution to inhibit proliferation to nasopharyngeal carcinoma cell was Curcumol > Curdione > β-Elemene > Germacrone > Curzerenone > α-Caryophyllene > δ-Selinene > β-Caryophyllene > β-Elemenone > a-Pinene > α-Caryophyllene > Eucalyptol > Camphor > 2-Nonanol > Isoborneol > Curzerene > δ-Elemene > Camphene > D-Limonene > Borneol. In conclusion, the study identified the effective components within C. kwangsiensisfor anti-tumor activities. This provided the spectrum-effect relationship in a type of traditional Chinese medicine, which is important for quality control and evaluation of complementary medicine. Key words: Curcuma kwangsiensis, spectrum-effect relationship, essential oil, gas chromatography-mass spectrometry.