Study on serum uric acid concentration and serum uric acid/creatinine ratio in patients with type 2 diabetes

Abstract

Objectives: 1. Determination of serum uric acid concentration and serum uric acid/creatinine ratio in patients with type 2 diabetes. 2. Find out correlations between serum uric acid, serum uric acid/creatinine ratio and some clinical and paraclinical characteristics in patients with type 2 diabetes. Materials and methods: 141 patients with type 2 diabetes, at the Examination Department of Khanh Hoa Provincial General Hospital from April 2022 to June 2023; method: cross-sectional descriptive study, data processing using SPSS 18.0 software. Results: men account for 56%, women account for 44%. The average age was 55.3 ± 9.7 year. The average time to detect diabetes is 9.4 ± 6.6 year. The rate of hypertension is 42.6%. The obesity rate is 26.2%. Average waist circumference: 81.06 ± 8.9 cm. Good fasting blood glucose control accounts for 39.0%, good HbA1c control accounts for 36.9%. The average GFR is: 83.42 ± 22.81 (ml/min/1.73m2), GFR reduction accounts for 11.3%, CKD accounts for 43.9%. The average serum UA concentration was: 345.87 ± 98.57 mmol/l, the average serum UA/Cre value was: 4.23 ± 1.3, with 23.4% increased serum UA. There is a negative correlation between UA and GFR, r = - 0.409. UA concentration in the group with CKD was higher than the group without CKD, p < 0.05. There is an association between UA according to CKD stage, p < 0.001. There is a relationship between UA/Cre according to CKD stage, p < 0.0001. There is a statistically significant relationship (p < 0.001) between UA concentration and urinary ACR level. Multivariable linear regression equation: GFR = 118.122 + 5.449*UA/Cre – 0.674*Age - 3.563*Urea - 0.014*ACR, with R2 = 64.1%, B = 5.449, p < 0.001. ROC curve analysis: Serum UA value: AUC = 0.767, p < 0.001, PI: 433.5, Se: 56.3%, Sp: 87.2%). Serum UA/Cre value: AUC = 0.131, p < 0.05. Conclusions: Serum UA/Cre ratio has prognostic value for CKD in patients with type 2 diabetes (R2 = 64.1%, B = 5.449). Serum UA concentration is valuable in predicting the occurrence of CKD in patients with type 2 diabetes (AUC = 0.767, cut-off point is 434 (µmol/l), with Se: 56.3% and Sp: 87.2%. Key words: diabetes, serum uric acid, serum uric acid/ creatinine ratio.