Study on role of ascorbic acid levels in PPROM and its maternal and perinatal outcome

Abstract

Background: Preterm premature rupture of membranes (PPROM) complicates 1–5% of all pregnancies and is the major contributory factor for perinatal morbidity and mortality. Micronutrient deficiency (vitamin C) is associated with increased risk of PPROM. This study was conducted to establish the association between maternal plasma vitamin C concentration in women with PPROM and women without PPROM and to study the difference in maternal morbidity, neonatal morbidity, and mortality. Objectives 1. Establish the association between maternal plasma vitamin C concentration in women with PPROM and women without PPROM.2. Study the association of anemia in vitamin C deficient patients with PPROM3.Study the difference in maternal and perinatal morbidity and mortality in both the groups Methods: This case controlstudy was conducted in Department of Obstetrics and Gynecology, EPIONE Hera Hospitals100 patients were studied, 50 were in study group (patients admitted to labour room with h/o PPROM) and 50 in the control group (patients admitted to labour room at term for delivery). Fasting blood sample was taken to measure the plasma vitamin C levels in both the groups. Results: Plasma vitamin C levels were low in PPROM patients and the concentration decreased as the pregnancy advanced, this proves linear relationship between plasma vitamin C levels and PPROM. The results of this study showed decreased plasma vitamin C levels leading to PPROM, preterm deliveries, increased NICU admissions, increased perinatal morbidity, mortality, maternal anemia in study group than in control group. Conclusion: As vitamin C deficiency during pregnancy leads to PPROM, it’s supplementation during pregnancy along with iron and calcium in second and third trimester should be made mandatory.