Study on Relationship between Serum Iron, Transferrin and Ferritin With Proteinuria in Adult Nephrotic Syndrome Patients in Vietnam

Abstract

Background: the loss of proteinuria in nephrotic syndrome (NS) patients reduces serum albumin and leads to many other changes such as dyslipidemia, disorders of blood clotting, disorders of hematopoietic components. The more and longer the loss of proteinuria occurs, the more pronounced these disorders are iron, transferrin and ferritin in serum. The objectives: Study the relationship between serum iron, transferrin and ferritin levels and proteinuria in NS patients. Subjects and Research Methods: randomized and controlled selection of 68 patients with NS in adults and without kidney failure; research according to the cross-descriptive method. Results: serum iron and transferrin levels in patients with NS are inversely correlated with proteinuria, with the following equations: y = -0.0633x + 9.531, R² = 0.0105 and y = -0.0041x + 0.725, R² = 0.0182; serum ferritin concentration positively correlated with proteinuria, with the equation y = 2.7432x + 583.65, R² = 0.0017.Conclusion: in NS serum iron and transferrin concentrations are inversely correlated with proteinuria, while serum ferritin is positively correlated with proteinuria.