Abstract
In the present study, we evaluated the hypoglycemic, hypolipidemic and anti-peroxidative effects of yam rice powder (YRP) derived from Tremella aurantialba on streptozotocin (STZ)-induced diabetic mice and diabetic patients. Diabetic mice were treated with ethanol extract of YRP (EEYR) at three doses or YRP for 30 days. Diabetic patients were treated with ethanol extract solution of YRP (ESYR) for 4.5 months. Results indicated that EEYR administration significantly reduced levels of fasting blood glucose (FBG), serum fructosamine, total cholesterol, total triglyceride and malondialdehyde, and increased glucose metabolism velocities and superoxide dismutase level in the serum compared with diabetic controls (p<0.01). Moreover, ESYR could replace chemical drugs to control the FBG and postprandial blood glucose levels of diabetic patients. Our results suggested that YRP could enhance hypoglycemic, hypolipidemic and antioxidant properties in STZ-induced diabetic mice and diabetic patients. Collectively, YRP might be used as food to prevent or manage diabetes.
Highlights
Yam rice powder (YRP) is prepared by solid-state fermentation of Tremella aurantialba using Chinese yam, rice and corn bran as feedstock
We have found that TBE and T. aurantialba mycelium polysaccharides (TMP) can reduce the blood glucose level (BGL) of the alloxan-induced diabetic mellitus rats, while TBE possesses stronger abilities to decrease the levels of total cholesterol (TC) and triglyceride (TG) in serum and enhance antioxidant capability [7]
After 12-h fasting on the day of animal sacrifice, fasting blood glucose (FBG) levels of all mice were determined using a blood glucose meter
Summary
Yam rice powder (YRP) is prepared by solid-state fermentation of Tremella aurantialba using Chinese yam, rice and corn bran as feedstock. YRP contains biomedicine components, such as polysaccharides and saponins. It has been proved that T. aurantiable is not poisonous, and it is used as food and medical drugs for thousands of years in many Asian countries due to its beneficial properties as follows, including immunoenhancing, anti-tumor, anti-hypoglycemic and anti-diabetic activities [15]. The extract from T. aurantialba broth (TBE, its main component is saponin) can regulate plasma glucose of type 2 diabetes in rats [6]. Chinese yam is the leading form of food staple for millions of people in tropical and subtropical countries. It is a tuber of Dioscorea polygonoides. Namely diosgenins, have been reported to be the active components of many yam species [8]. Our findings provided valuable insights into the mechanism underlying the anti-diabetic effects of YRP
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