Study on proliferative activity of endocrine cells in gastric carcinoma

Abstract

Endocrine cell (EC) in 11 cases picked up from 56 cases of gastric carcinoma were observed by double immunohistochemical method using chromogranin A(CgA) and proliferating cell nuclear antigen (PCNA) . The endocrine cells were recognized by a antibody to CgA and the proliferative activity by a monoclonal antibody to PCNA. 11 cases CgA positive GC cells with PCNA incorporation was in 51/4069 (0-3%) with an average 1.25%. By contrast, PCNA reaction was positive in 31.9±14.7% of CgA negative GC cells. It suggests that there were a few cell in S and G 1 phase and most of them in G 0 phase.