Study on prevalence of Vancomycin Resistant Enterococcus and high level Gentamicin resistance among Enterococcus isolates in a Pediatric tertiary care hospital

J Bhavana,Kaarthiga S,Mahantesh Mahantesh,Yadukul S

doi:10.18231/j.ijmmtd.2020.042

Abstract

Vancomycin resistance and high level aminoglycoside resistance in Enterococci has limited its treatment, as Enterococci are susceptible to only narrow spectrum of antibiotics. VRE is known to cause hospital acquired infections. This study was aimed to determine prevalence of vancomycin resistance and HLG resistance among Enterococci in a Pediatric hospital. 310 spp was isolated between Jan 2018- May 2020 from pediatric patients from various samples. Among them 206 (66.5%) isolates were , 104 (33.5%) isolates were spp including . Most of the isolates were from urine (68%). High Level Gentamicin (HLG) resistance was seen in 69% of the isolates. Vancomycin resistance (VRE) was seen in 29 (9.4%) isolates. HLG resistance among VRE was 79% (23/29), all of them were sensitive to Linezolid. 17 of the VRE isolates were from urine sample and 15 (88%) of these isolates were sensitive to Nitrofurantoin. 90% (26/29) of the VRE isolates were isolated from nosocomial infections. 58% of VRE isolates were

Highlights

Enterococcus spp are present as commensals mainly in the gastrointestinal tract in humans
High Level Gentamicin (HLG) resistance among Vancomycin resistance (VRE) was 79% (23/29), all of them were sensitive to Linezolid. 17 of the VRE isolates were from urine sample and 15 (88%) of these isolates were sensitive to Nitrofurantoin. 90% (26/29) of the VRE isolates were isolated from nosocomial infections. 58% of VRE isolates were Enterococcus faecalis
A total of 310 Enterococcus spp was isolated between Jan 2018- May 2020 from pediatric patients aged between 1 day- 18 years and from various samples in Department of Microbiology, in a Pediatric tertiary care hospital

Summary

Introduction

Enterococcus spp are present as commensals mainly in the gastrointestinal tract in humans. They can survive in environment, in adverse environmental conditions like drying and high temperature to a certain extent. They are known to cause infections like urinary tract infections, wound infection and blood stream infections primarily in debilitated patients. 1 Resistance to fluoroquinolones and high level Gentamicin(HLG) has become common among Enterococcus. Vancomycin is the main drug of choice for treating systemic infections. Emergence of Vancomycin Resistant Enterococcus (VRE) has possessed a greater threat in its treatment.[2] VRE is a potent nosocomial pathogen. VRE is a potent nosocomial pathogen. 1,2 Surveillance for VRE becomes very important to prevent its cross infection. 3

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