Abstract
Systems for targeted drug delivery in the treatment of cancer using nanoparticles are currently of interest to many domestic and foreign scientists. In this work, for application as a target drug delivery system in the treatment of breast cancer Fe3O4@lapatinib nanoparticles were prepared by coprecipitation of solutions of Fe2+ and Fe3+ salts in alkaline, followed by purification in a magnetic separation system. Physicochemical properties of nanoparticles were studied and determined by XRD, TEM, DLS, HPLC, VSM, AAS and zeta potential methods. The results showed that the size of Fe3O4@lapatinib nanoparticles is in the range of 10 to 40 nm, hydrodynamic diameter is 27.4 ± 0.6 nm, saturation magnetization is 39.1 ± 3.1 emu/g, Fe content is 16.35 ± 0.97 mg/ml, lapatinib content is 8.08 ± 0.06 mg/ml, and the zeta potential is -16.2 ± 1.3 mV. Thus, the obtained Fe3O4@lapatinib nanoparticles are fully suitable for targeted drug delivery in the breast cance treatment
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
