Abstract
Polyurethane hydrogel(PUHG), which exhibits pH, temperature and ionic intensity sensitive, was synthesized by using the toluene diisocyanate(TDI), polyethylene glycol(PEG-6000), dimet hylol propionic acid(DMPA) and triethylene tetramine(TEFA).The effect of pH, temperature, ionic intensity and crosslinking agent on welling ratio of the PUHG was studied in detail . The result showed that the swelling ratio of PUHG decreased with the temperature increasing between 20 and 45˚C but didn't change after 45˚C; in alkaline medium (pH=9), the swelling ratio of the PUHG was more than that of In acid medium (pH=4), which indicated it had a good sensitivity; the swelling ratio of PUHG decreased with ionic intensity increasing at a temperature and pH. The results of swelling dynamic indicated that PUHG can change reversibly well at different pH and temperature. So the PUHG is suitable for use in biomedical controlled delivery of medicines.
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