Abstract
AbstractThe distribution behavior of chlorpromazine hydrochloride (CPZ), procaine hydrochloride (PCN) and procaine amide hydrochloride (PCNA) in polyethylene glycol (PEG800 or PEG1500)‐(NH4SO4 aqueous two‐phase systems has been investigated. The result shows that the PEG‐(NH4SO4 aqueous two‐phase system has potential extraction capability in small molecular drug separation. In PEG800–(NH4)2SO4 system, the extraction efficiencies (E) of CPZ, PCN and PCNA amount to 92.8%, 74.5% and 74.4%, respectively, with the distribution coefficients (KD) being 25.7, 5.9 and 5.8, correspondingly. In PEG1500–(NH4)2SO4 system, the extraction efficiencies (E) of CPZ, PCN and PCNA are 93.7%, 71.3% and 63.24, respectively, with distribution coefficients (KD) of 39.6, 6.6 and 5.0, correspondingly. Based on the study on ultraviolet and fluorescence spectra and also distribution behavior of the drugs in PEG‐(NH4)SO4 aqueous two‐phase system, extraction mechanism was further proposed that both hydrogen bond and hydrophobic interaction are involved in extraction.
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