Abstract
The introduction of functionalized magnetizable particles and high-gradient magnetic separation represents a time and money saving alternative to conventional purification and separation unit operations in the biotechnical sector. This technique has some advantages especially for the recycling of immobilized enzymes. A new magnetic filter with sight glasses was constructed and produced to study the performance of high-gradient magnetic separation at varied parameters. By optical analysis the buildup of a clogging was identified as the major parameter which affected the separation performance. For the cleaning procedure, a two-phase flow of water with highly dispersed air bubbles was tested which led to a nearly complete cleaning of the filter chamber.
Highlights
High-gradient magnetic separation is a technique used for several separation tasks
During the research on optimizing and improving high-gradient magnetic separation, it was found that the magnetic particle deposits on the filter matrix influenced the particle retention
In the publications of Menzel et al [9] and Mizuno et al [10] particle deposits were shown after a filtration by taking the filter matrix out of the filter chamber
Summary
High-gradient magnetic separation is a technique used for several separation tasks. The use of the magnetic force enables a simple separation of a biotechnological catalyst which is immobilized on a magnetizable carrier. Because there is no need of inner surface area, the biocatalytic active surface is accessible due to the absence of porous diffusion. This provides major advantages for the reaction due to better. (2016) Study on Optimizing High-Gradient Magnetic Separation—Part 2: Experimental Evaluation of the Performance of a New Designed Magnetic Filter. In a high-gradient magnetic separator, a filter matrix is inserted in the filter chamber to build a highly inhomogeneous magnetic field [3]-[8]. During the research on optimizing and improving high-gradient magnetic separation, it was found that the magnetic particle deposits on the filter matrix influenced the particle retention. In the work of Käppler [21], a model for estimating the particle load in dependence to the filter length was introduced under the assumption that the magnetic particle deposits were distributed homogeneously over the cross-section perpendicular to the fluid flow
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