Abstract
The noncovalent complexes of four cytotoxic protoberberine alkaloids that is, berberine, palmatine, jatrorrhizine, and coptisine with double-stranded oligodeoxynucleotides d(AAGAATTCTT) 2 were investigated by electrospray ionization mass spectrometry. These four active components from Chinese herbal medicines showed both 1:1 and 1:2 binding stoichiometries, independent on the alkaloid-to-DNA ratios. Binding affinities in the order of palmatine ⩾ jatrorrhizine > coptisine > berberine with d(AAGAATTCTT) 2 were obtained. Additionally, the preliminary results indicated that berberine had some sequence selectivities.
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