Abstract
Publisher Summary This chapter presents a study of microphage functions in lichen rubber planus (LP). Investigations included 21 untreated LP patients (mean age 44 years) and 100 clinically healthy sex- and age-matched individuals. Polymorphonuclear leucocytes (PMNLs) were separated from peripheral blood using Boyum's method (1968). Chemotaxis of PMNLs was tested by means of the in filter count technique, using a modification of Boyden's method. Intracellular killing activity and phagocytosis of Candida albicans (C. albicans) blastospores were assessed by applying Lehrer's method (1972) and by the NADH-dependent oxidase activity. In 12 of 21 patients, a slightly restricted chemotaxis was observed using mussel glycogen as a chemoattractant during incubation in autologous serum. In 14 patients, the percentage of intracellularly killed C. albicans blastospores was markedly reduced. Phagocytic capacity and the NADH-dependent oxidase activity of PMNLs appeared to be intact. The present data indicate that in patients suffering from LP besides some signs of increased T-cell activity the unspecific PMNL system also tends to deviate from its normal functional pattern.
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