Abstract
In this project, the adequacy of different layouts for Paper-based Analytical Device (μPAD) for simultaneous analysis in mixtures was evaluated through the use of colorimetric reactions in their reactional zones. Hence, the following parameters of the μPAD were varied: width of the hydrophobic barrier, width and length of the hydrophylic channel, shape and dimensions of the reactional zones, and geometry of the device. The analytical system used in this research was based in comercial tests for domestic quality control of pool water with pH measure through Phenol Red deprotonation, and free chlorine determination through o-Toluidine oxidation.
Highlights
Microfluidics refers to the manipulation of fluids in the scale of micro to nano liters with analytical applications in a series of fields like clinical diagnostics[1] and environmental monitoring[2]
The best geometry found for the simultaneous determination of the two selected analytes was the linear one, which generated a more homogeneous colored spot using a smaller sample volume and with the least risk of cross contamination due to having the biggest distance between the reactional zones
The smallest width for the hydrophobic barrier found was of 0.2 mm; being a circle of 8.25 mm diameter was the best shape for the reactional zones, with hydrophilic channels of 2.0 x (4.12 to 8.25) mm giving the best results (Image 2)
Summary
Microfluidics refers to the manipulation of fluids in the scale of micro to nano liters with analytical applications in a series of fields like clinical diagnostics[1] and environmental monitoring[2]. Study on Microfluidic Paper-based Analytical Device layouts for simultaneous analysis purposes applying colorimetric reactions Abstract In this project, the adequacy of different layouts for Paper-based Analytical Device (μPAD) for simultaneous analysis in mixtures was evaluated through the use of colorimetric reactions in their reactional zones.
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