Abstract
In order to study the mechanical properties of new iliac vein stents in different stenotic vessels, the release process of four stents in iliac vein with different stenosis rates (normal, 30%, 50%, 70%) was simulated by finite element method, the influence of stenosis rate on the mechanical properties of stents was analyzed, and the safety of stents was verified by animal experiments. The results showed that the high stress-strain regions of the four stents were all located in the stenosis area. With the increase of the stenosis rate, the equivalent stress and elastic strain of the stents tended to increase. After fatigue calculation, the safety factor of the fatigue strength of the stent is more than 1, which meets the requirement of 10 years fatigue life. To establish an animal model of iliac vein stenosis, the endothelial cells were covered on the surface of the stent 90 days after stent implantation, the intima was proliferated obviously, and the mechanical properties and biocompatibility of the stent were stable. The new type of stent for iliac vein stenosis could be used as the main experimental instrument in later animal experiments.
Highlights
Iliac Vein Compression Syndrome (IVCS) is a disease that causes the left iliac vein to be compressed and stimulated by the posterior lumbosacral vertebra and the anterior right iliac artery
It was possible to conclude that finite element method (FEM) can simulate the stress behavior, deformation behavior and fatigue behavior of stent release in different stenotic vessels, and the results are verified by animal experiments
The first relevant finding is that when the stent is released in the stenotic vessel, with the increase of the stenosis rate, the equivalent stress and elastic strain of stent will increase
Summary
Iliac Vein Compression Syndrome (IVCS) is a disease that causes the left iliac vein to be compressed and stimulated by the posterior lumbosacral vertebra and the anterior right iliac artery. Meoli et al.[3,4,5] analyzed the fatigue behavior of Ni-Tinol stents subjected to cyclic axial compression and bending during full dilation and deployment. This process of examination, helped to find that the interaction between stents and blood vessels must be considered, and the excessive dilation of stents and blood vessels should not be neglected, 2012 to 2014.
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