Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V.

Chenglong Shi,Nana Lu,Yaru Qin,Mingdi Liu,Hongxia Li,Haichao Li,Jose Manuel Garcia Aznar

doi:10.1371/journal.pone.0247764

Chenglong Shi, Nana Lu + Show 5 more

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https://doi.org/10.1371/journal.pone.0247764

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Abstract

In this paper, we take the elliptical pore structure which is similar to the microstructure of cancellous bone as the research object, four groups of bone scaffolds were designed from the perspective of pore size, porosity and pore distribution. The size of the all scaffolds were uniformly designed as 10 × 10 × 12 mm. Four groups of model samples were prepared by selective laser melting (SLM) and Ti6Al4V materials. The statics performance of the scaffolds was comprehensively evaluated by mechanical compression simulation and mechanical compression test, the manufacturing error of the scaffold samples were evaluated by scanning electron microscope (SEM), and the permeability of the scaffolds were predicted and evaluated by simulation analysis of computational fluid dynamics (CFD). The results show that the different distribution of porosity, pore size and pores of the elliptical scaffold have a certain influence on the mechanical properties and permeability of the scaffold, and the reasonable size and angle distribution of the elliptical pore can match the mechanical properties and permeability of the elliptical pore scaffold with human cancellous bone, which has great potential for research and application in the field of artificial bone scaffold.

Highlights

Natural bone is a kind of interconnected porous material, which is mainly composed of external dense cortical bone and internal soft cancellous bone [1]
In the comparison of existing experimental results, the elastic modulus and yield strength of the gyroid bone scaffold designed by Ataee et al were 1465~2676 MPa and 44.9~56.5 MPa, respectively [14], which were close to the elastic modulus of trabecular bone
Mechanical simulation analysis and experimental results show that the four groups of elliptical pore scaffolds have the strength and rigidity that match the human native bone tissue, and SAP scaffolds have greater stiffness and yield strength

Summary

Introduction

Natural bone is a kind of interconnected porous material, which is mainly composed of external dense cortical bone and internal soft cancellous bone [1]. The internal pore structure is very important for the infiltration, proliferation, differentiation and migration of cells [2, 3]. A large area of bone defect in human body needs external intervention [4]. Autografts and allografts are the common treatment of clinical bone defect diseases [5, 6]. It is very important to develop a suitable substitute for human bone tissue.

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