Study on Maximum Specific Loss Power in Fe3O4 Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia.

Costica Caizer,Isabela Simona Caizer

doi:10.3390/ijms221810071

Abstract

Different chemical agents are used for the biocompatibility and/or functionality of the nanoparticles used in magnetic hyperthermia to reduce or even eliminate cellular toxicity and to limit the interaction between them (van der Waals and magnetic dipolar interactions), with highly beneficial effects on the efficiency of magnetic hyperthermia in cancer therapy. In this paper we propose an innovative strategy for the biocompatibility of these nanoparticles using gamma-cyclodextrins (γ-CDs) to decorate the surface of magnetite (Fe3O4) nanoparticles. The influence of the biocompatible organic layer of cyclodextrins, from the surface of Fe3O4 ferrimagnetic nanoparticles, on the maximum specific loss power in superparamagnetic hyperthermia, is presented and analyzed in detail in this paper. Furthermore, our study shows the optimum conditions in which the magnetic nanoparticles covered with gamma-cyclodextrin (Fe3O4–γ-CDs) can be utilized in superparamagnetic hyperthermia for an alternative cancer therapy with higher efficiency in destroying tumoral cells and eliminating cellular toxicity.

Highlights

In alternative cancer therapy, magnetic hyperthermia and/or superparamagnetic hyperthermia has been used with very promising results in vitro and in vivo [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18]
The magnetic hyperthermia effect in this case is obtained through the superparamagnetic relaxation effect [25,26]; this type of hyperthermia is known as superparamagnetic hyperthermia
With a view to the elimination of the cellular toxicity of Fe3O4 nanoparticles and the elimination of the van der Waals and magnetic dipolar interactions that lead to nanoparticle agglomeration in large structures, with negative effects on superparamagnetic hyperthermia; in this paper we proposed biocompatibilization of the Fe3O4 nanoparticles through the decoration of their surface with gamma-cyclodextrins (γ-CDs) [30,31], for a significant beneficial effect on magnetic hyperthermia

Summary

International Journal of Molecular Sciences

Citation: Caizer, C.; Caizer, I.S. Study on Maximum Specific Loss Power in Fe3O4 Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia. Int. J. Mol. Sci. 2021, 22, 10071. https://doi.org/10.3390/ ijms221810071

Introduction

Results and Discussion

Observables Values

ObservableOsbservables f

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