Abstract
Monodisperse cationic polystyrene nanoparticles (PS-NPs) were prepared through microemulsion polymerization. Photon correlation spectrometry and transmission electron microscopy revealed that these cationic PS-NPs have a z-average particle size of 30 nm. Size analysis, circular dichroism spectroscopy and transmission electron microscopy indicate that the PS-NPs nanoparticles undergo electrostatic interaction with DNA to form a PS–DNA complex that obviously enhances the resonance light scattering (RLS) signal. A method is presented where the PS-NPs act as a probe for the detection of DNA by RLS. The method is convenient, sensitive, reproducible, and enables high-throughput. The PS-NPs are inexpensive and exhibit low toxicity.
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